A research peptide known as PT-141, also known as Bremelanotide, is now being investigated for the possibility that researchers might use it to assist in treating sexual dysfunction.
PT-141 was developed from the tanning peptide Melanotan 2, a variant of a peptide hormone naturally produced in the body and known as an Alpha-Melanocyte stimulating hormone. This hormone is responsible for stimulating melanogenesis. Synthetically produced Melanotan 2 is a variant of the alpha-Melanocyte stimulating hormone.
While exerting its effects, MSH is responsible for activating a subset of melanocortin receptors. MSH has significantly impacted lipid metabolism, hunger, and sexual drive. Consequently, PT-141 has been shown in tests to display libido-enhancing effects via activating the melanocortin receptors MC1R and MC4R, even though it does not cause skin tanning.
Because of the melanogenesis-stimulating capabilities that Melanotan 1 and Melanotan 2 possess, they have also been the subject of study into the possibility that they may be used as a kind of protection against the potentially damaging effects of UV radiation from the sun.
The Beginnings of PT-141
Melanotan 2 Peptide was tested as a self-tanning agent before developing PT-141, derived from that peptide. Melanotan 2 did cause tanning during the first round of testing, but, as an unanticipated side effect, it also generated sexual excitation and spontaneous erections in nine out of ten of the original male volunteer test participants.
Palatin has finished treating patients as part of its Phase 2B clinical study in premenopausal females with FSD. Primary data analysis and presentation of top-line findings occurred in the first part of the fourth quarter of 2012. Studies have demonstrated that PT-141 is a successful treatment for erectile dysfunction (also known as impotence) and other forms of sexual dysfunction in males and females (sexual arousal disorder). It does not work on the circulatory system like Viagra or other medications in its class but rather enhances sexual desire directly via the neurological system.
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Reconstitution
Before opening this vial, we advise giving it a quick spin in a centrifuge to let the contents fall to the bottom of the container. Reconstitute the product to a concentration of 0.1-1.0 mg/mL in sterile distilled water or an aqueous buffer containing 0.1% BSA. The stock solutions should be divided into working aliquots and kept at a temperature of fewer than -20 degrees Celsius. It is recommended that further dilutions be done in solutions that have been appropriately buffered.
Storage
This lyophilized preparation may be stored safely at ambient temperature as long as it is protected from light. Still, for long-term preservation, it must be maintained at -20 degrees Celsius, ideally with a desiccant. After reconstituting, researchers may safely keep the preparation at temperatures between 2 and 8 degrees Celsius. The reconstituted product should be divided into working aliquots and stored at a temperature of -20 degrees Celsius for optimal stability. Stay away from cycles of freezing and thawing.
